Abstract Search

ey0015.5-5 | New genes and gene mutations | ESPEYB15

5.5 Aggrecan Mutations in Nonfamilial Short Stature and Short Stature Without Accelerated Skeletal Maturation

C Tatsi , A Gkourogianni , K Mohnike , D DeArment , S Witchel , AC Andrade , TC Markello , J Baron , O Nilsson , YH Jee

To read the full abstract: J Endocr Soc 2017;1:1006-1011Besides its structural role in the extracellular matrix, aggrecan orchestrates a plethora of key mechanisms in endochondral ossification, such as embryonic morphogen distribution, regular indian hedgehog (IHH) / Sox9 expression and columnar chondrocyte orientation. Thus, homozygous loss-of-function mutations in the ACAN gene, encoding...

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ey0020.3-19 | Advances in Growth, Bone Biology, and Mineral Metabolism | ESPEYB20

3.19. The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation

M Chau , Z Dou , M Baroncelli , EB Landman , A Bendre , M Kanekiyo , A Gkourogianni , K Barnes , L Ottosson , O Nilsson

In Brief: Growth plate and articular cartilage have similar structures composed of distinct chondrocyte layers but they differ substantially with respect to their function and fate. This study combines transplantation experiments with cell tracing in rat with in vitrostudies to identify a novel mechanism by which synoviocytes act directly on chondrocytes to suppress endochondral and promote articular cartilage at the joint surface.Commentary: Gr...

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ESPE Yearbook of Paediatric Endocrinology

5.5 Aggrecan Mutations in Nonfamilial Short Stature and Short Stature Without Accelerated Skeletal Maturation

3.19. The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation

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